Synthesis of novel 3-pyridinecarbonitriles with amino acid function and their fluorescence properties |
| |
Authors: | A S Girgis A Kalmouch H M Hosni |
| |
Institution: | (1) Pesticide Chemistry Department, National Research Centre, Dokki, Cairo, Egypt;(2) Tanning Materials and Protein Chemistry Department, National Research Centre, Dokki, Cairo, Egypt |
| |
Abstract: | Summary. A variety of N-(4,6-diaryl-3-pyridinecarbonitrile)-2-yl] amino acid esters 2–4 were synthesized through the reaction of 2-bromo-3-pyridinecarbonitriles 1 with the appropriate -amino acid ester hydrochloride in refluxing dioxane in the presence of triethylamine as dehydrohalogenating agent. Similarly, N-glycylglycine analogues 5 were obtained through the reaction of 1 with the dipeptide ester. On the other hand, attempts were made towards the construction of amino acid derivatives 7 through the reaction of 1 with aqueous solution -amino acids 6 in refluxing pyridine, but were unsuccessful, and instead the unexpected 2-amino-3-pyridinecarbonitriles 8 were isolated. The fluorescence properties of the newly synthesized pyridines 2–5 were evaluated. Some of the prepared compounds show considerable antibacterial activity. |
| |
Keywords: | : 3-Pyridinecarbonitriles – -Amino acids –" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">-Amino acids – Aromatic nucleophilic substitution – Fluorescence properties |
本文献已被 PubMed SpringerLink 等数据库收录! |
|