Recombinant gamma interferon enhances natural killer cell activity similar to natural gamma interferon |
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| Authors: | D A Weigent G J Stanton H M Johnson |
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| Affiliation: | Department of Microbiology The University of Texas Medical Branch Galveston, Texas 77550 USA |
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| Abstract: | ![]()
The enhancement of human natural killing activity by recombinant human gamma interferon (IFNγ) and natural human IFNγ were similar over a wide concentration range. Enhancement of natural killing activity by both interferons was neutralizable by antibody to natural IFNγ, as well as by antibody to a synthetic peptide representing the first 20 N-terminal amino acids of IFNγ provide conclusive evidence that IFNγ is responsible for the enhanced natural killing activity seen in IFNγ preparations. |
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| Keywords: | IFNγ gamma interferon NK natural killing CPE cytopathogenic effect FBS fetal bovine serum |
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