虎眼万年青多糖降血糖作用的研究

目的:研究虎眼万年青多糖对四氧嘧啶诱导的糖尿病小鼠的降糖作用以及对糖尿病相关特征的影响。方法:采用腹腔注射四氧嘧啶致糖尿病小鼠模型;分成阳性药物组、模型对照组、空白对照组、虎眼万年青多糖高、中、低剂量组,连续给药14d,观察糖尿病小鼠的体重、血糖水平、总胆固醇(TG)和甘油三脂(TC)的变化。结果:经灌胃给药14d后,与空白对照组比较,模型组小鼠体质量呈下降趋势(P0.01),血糖值(P0.01)、总胆固醇TG(P0.01)、甘油三酯TC(P0.01)均明显上升;与模型组比较,虎眼万年青多糖高、中剂量组能有效降低糖尿病小鼠的血糖水平(P0.01),总胆固醇TG(P0.01),甘油三脂TC(P0.01),并且虎眼万年青多糖高剂量组可缓解糖尿病小鼠体重减轻症状(P0.01),而低剂量组作用效果不明显(P0.05)。结论:虎眼万年青多糖能够降低四氧嘧啶致糖尿病小鼠血糖水平,改善血脂代谢紊乱。

Study on Hypoglycemic Effect of Polysaccharide from Ornithogalum Caudatum Ait

ABSTRACT Objective: To study the hypoglycemic effect of Ornithogalum Caudatum Ait polysaccharide on the alloxan -induced diabetic model mice and the effect on diabetes relevant characteristics. Methods: A mouse model of diabetes was established by intraperitoneal injection of alloxan. The diabetic mice were divided into six groups: the group of positive drug, the comparison group in the model mice, the blank control group, the groups of high, medium and low dose polysaccharide from Ornithogalum Caudatum Ait. After 14d administered of Ornithogalum Caudatum Ait polysaccharide, blood glucose levels, body weight, total cholesterol and triglyceride in diabetic mice were observed. Results: After intragastric administration for 14d, compared with the blank control group, the body weight of the model group showed a downward trend(P<0.01), while the blood glucose, total cholesterol and triglyceride were increased significantly(P<0.01). The groups of high, medium dose polysaccharide from Ornithogalum Caudatum Ait can significantly reduce the level of blood glucose, total cholesterol and triglyceride of diabetic mice in comparison with the comparison group in the model mice(P<0.01), besides the group of high dose polysaccharide from Ornithogalum Caudatum Ait can relieve the symptoms of weight loss in diabetic mice(P<0.01). But the effect of low dose group is not obvious(P>0.05). Conclusion: The polysaccharides from Ornithogalum Caudatum Ait can reduce the blood glucose level of diabetic mice induced by alloxan and improve blood lipids metabolic disorder.