干细胞衰老与衰老微环境调控的研究进展

干细胞衰老会损害机体组织的稳态,衰老的干细胞丧失修复能力从而引发衰老相关疾病。衰老微环境是促进机体衰老的重要因素之一。衰老相关分泌表型(SASP)是构成衰老微环境的主要成分,影响干细胞的组织修复能力,进而推动机体衰老进程。细胞外囊泡(EVs)被认为在衰老微环境中发挥重要作用,衰老细胞分泌的EVs通过运载mi RNAs等非编码RNA及SASP在内的多种活性分子参与调控衰老微环境,本文就干细胞衰老的诱发因素以及衰老微环境的研究进展进行综述,以期为干细胞的临床应用提供实验基础和理论基础。

The Progress on Researches in Stem Cell Aging and Regulation of Aging Microenvironment

ABSTRACT: The aging of stem cells impairs the homeostasis in the tissue. Aged stem cells lose their ability to repair tissue and cause the age-related diseases. Senescent microenvironment is one of the important factors which lead to organism aging. The senes- cence-associated secretory phenotype (SASP) is an important part of senescent microenvironment. The SASP affects the ability of stem cells to repair and drives the process of aging. Extracellular vesicles (EVs) are thought to play an important role in senescent microenvi- ronment. EVs secreted by senescent cells carry non-coding RNA such as miRNAs and a variety of active molecules including SASP, which are involved in the regulation of senescent microenvironment. This paper reviews the reasons of the stem cells aging and the re- search progress of senescent microenvironment, so as to provide the experimental basis and theoretical basis for the clinical application of stem cells.