乳腺癌功能磁共振成像与生物学预后因子的研究进展

乳腺癌已成为女性最为常见的恶性肿瘤,如何对乳腺癌进行早期诊断、合理化治疗及判断预后意义重大。雌激素受体(ER)、孕激素受体(PR)、Ki-67、人表皮生长因子受体2(HER-2)等免疫组化指标在判断乳腺癌临床类型、转移情况及预后等方面具有重要作用。随着功能磁共振的发展,氢质子磁共振波谱(1H-MRS)、动态增强磁共振成像(DCE-MRI)、扩散加权成像(DWI)等被越来越广泛的用于乳腺组织的检查。研究功能磁共振与乳腺癌预后因子的相关性,对乳腺癌的临床分型、治疗及预后等方面有一定的指导作用。本文就相关进展进行综述。

Advances in Functional Magnetic Resonance Imaging and Biological Prognostic Factors in Breast Cancer

ABSTRACT: Breast cancer has become the most common malignant tumor in women, it is of great significance to early diagnosis, rational treatment and prognosis of breast cancerprogesterone receptor (ER), progesterone receptor (PR), Ki-67, human epidermal growth factor receptor 2 (HER-2) and other immunohistochemical markers in breast cancer to determine the clinical type, metastasis and progno- sis plays an important role. With the development of functional magnetic resonance imaging, such as proton magnetic resonance spec- troscopy (1H-MRS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion weighted imaging (DWI) and so on are more and more used for the examination of the breast. To study the correlation of functional magnetic resonance imaging in breast cancer diagnosis and prognosis factors of breast cancer, and to guide the clinical treatment and prognosis of breast cancer. In this paper, the related progress were summarized.