松龄血脉康胶囊联合立普妥对老年高血压患者血清Fibulin-3、Lp(a)、MCP-1水平的影响

目的:研究松龄血脉康胶囊联合立普妥对老年高血压患者血清细胞外基质蛋白-3 (Fibulin-3)、脂蛋白a (Lipoprotein(a),Lp(a))、单核细胞趋化蛋白-1 (monocyte chemoattractant protein-1,MCP-1)水平的影响。方法:选择2015年04月至2017年12月在我院治疗的老年高血压患者72例,按照随机数字表法为观察组和对照组,对照组采用立普妥口服治疗,观察组在对照组的基础上联用松龄血脉康胶囊口服治疗,观察和比较两组临床治疗效果,治疗前后血脂、动态血压及Fibulin-3、Lp(a)、MCP-1水平的变化情况。结果:治疗后,观察组总有效率为88.89%,明显高于对照组(69.44%,P0.05);观察组血清血清总胆固醇(Serum total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、甘油三酯(triglyceride,TG)、游离脂肪酸(nonesterified fatty acid,FFA)、Lp(a)、MCP-1等水平均显著低于对照组(P0.05),而血清HDL-C、Fibulin-3水平明显高于对照组(P0.05);治疗后,观察组动态血压水平降低范围较对照组更明显(P0.05);观察组患者生活愉快、心理健康及认知功能等方面评分均显著高于对照组(P0.05)。结论:松龄血脉康胶囊联合立普妥治疗老年高血压患者的临床疗效显著优于单用立普妥口服治疗,其能更有效维持动态血压的正常水平,且显著改善Fibulin-3、Lp(a)、MCP-1水平,降脂效果良好。

Effects of Tongling Kumaikang Capsule Combined with Lipitor on the Serum Fibulin-3, Lp (a) and MCP-1 Levels in Elderly Patients with Hypertension

ABSTRACT Objective: To study effects of tongling kumaikang capsule combined with lipitor on serum Fibulin-3, Lp(a) and MCP-1 in elderly hypertensive patients. Methods: 72 patients of patients with elderly hypertension who received therapy from from April 2015 to December 2017 were selected as research objects. According to the random number table method, the observation group and the control group. The The control group was treated with Lipitor. The observation group was treated with songling blood capsule on the basis of the control group.The levels of clinical efficacy, blood lipid, ambulatory blood pressure and Fibulin-3, Lp (a) and MCP-1 were observed. Results: After treatment, the total effective rate was 88.89% in the observation group, which was higher than that in the control group (69.44%), and the difference was statistically significant (P<0.05). After treatment, the levels of TC, LDL-C, TG and FFA in the observation group were less than those in the control group, and HDL-C was higher than that in the control group (P<0.05). After treatment, the level of am- bulatory blood pressure in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the scores of the observation group were significantly higher than those of the control group(P<0.05) in the aspects of happy life, mental health and cognitive function. After treatment, the levels of Lp (a) and MCP-1 in the observation group were significantly lower than those in the control group, and the level of Fibulin-3 in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: The clinical efficacy of songling xuemaikang capsule combined with lipitor in the treatment of elderly patients with hy- pertension is significantly better than that of lipitor alone, which can effectively maintain the normal level of dynamic blood pressure and significantly improve the level of fibulin-3, Lp(a), McP-1, with good lipid lowering effect.