幽门螺旋杆菌感染与慢性胃炎患者IL-8、IL-10、CRP水平以及血脂指标的关系研究

目的:研究幽门螺旋杆菌(Hp)感染与慢性胃炎患者白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、C反应蛋白(CRP)水平以及血脂指标的关系。方法:选择从2015年6月到2017年6月在我院接受治疗的慢性胃炎患者150例作为观察组,根据13C-尿素呼吸实验的结果将观察组患者分成HP阳性组71例和Hp阴性组79例,另选同期在我院进行健康体检的志愿者150例作为对照组,对比观察组以及对照组的炎症因子IL-8、IL-10、CRP及血脂指标低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]水平,并对比观察组不同HP感染情况的炎症因子及血脂指标水平,分析Hp感染与患者炎症因子及血脂指标水平的相关性。结果:观察组的IL-8、IL-10、CRP、LDL-C及TG水平均分别高于对照组,差异均有统计学意义(均P0.05)。Hp阳性组患者治疗前的IL-8、IL-10、CRP、LDL-C及TG水平均分别高于HP阴性组,但Hp阳性组患者治疗后的上述指标水平均分别低于HP阴性组,差异均有统计学意义(均P0.05)。两组治疗后的IL-10、CRP水平均分别低于治疗前,且Hp阳性组患者的IL-8、LDL-C及TG水平也低于治疗前,差异均有统计学意义(均P0.05),Spearman相关性分析结果显示,Hp感染与患者IL-8、IL-10、CRP、LDL-C及TG水平均呈正相关(均P0.05),但Hp感染与HDL-C和TC并无明显的相关性(P0.05)。结论:Hp感染与慢性胃炎患者的炎症指标及血脂指标关系紧密,临床上可考虑将此类指标作为存在Hp感染的慢性胃炎患者的监测指标,从而更好地辅助临床诊治。

Relationship Between Helicobacter Pylori Infection and Levels of IL-8, IL-10, CRP and Blood Lipid Indexes in Patients with Chronic Gastritis

ABSTRACT Objective: To study the relationship between Helicobacter pylori (HP) infection and the levels of interleukin-8(IL-8), interleukin-10(IL-10), C reactive protein (CRP) and blood lipid indexes in patients with chronic gastritis. Methods: A total of 150 patients with chronic gastritis, who were treated in Langfang People''s Hospital from June 2015 to June 2017, were chosen as observation group.According to the experimental results of 13C- urea breath, the patients of observation group were further divided into Hp positive group (n=71) and HP negative group(n=79). At the same time, 150 volunteers, who underwent physical examination in this hospital, were cho- sen as control group. The levels of inflammatory cytokines such as IL-8, IL-10, and CRP and blood lipid indexes such as low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), triglyceride (TG), total cholesterol (TC) were compared between the observation group and the control group. The levels of inflammatory factors and blood lipid indexes of the patients with different Hp infection in the observation group were compared. The correlation between HP infection and levels of inflammatory factors and blood lipid indexes of the patients were analyzed. Results: The levels of IL-8, IL-10, CRP, LDL-C and TG in the observation group were significantly higher than that in the control group, the differences were statistically significant(P<0.05). The levels of IL-8, IL-10, CRP, LDL-C and TG of Hp positive group before treatment were significantly higher than those of HP negative group, but the above indexes of the HP positive group were lower than those of the Hp negative group, the differences were statistically significant(P<0.05). The levels of IL-10, CRP of the two groups after treatment were significantly lower than those before treatment, the levels of IL-8, LDL-C and TG of Hp positive group were significantly lower than those before treatment, the differences were statistically significant(P<0.05). Spearman correlation analysis showed that Hp infection was positively correlated with the levels of IL-8, IL-10, CRP, LDL-C and TG of the patients(P<0.05), but there was no significant correlation between Hp infection and HDL-C and TC (P>0.05). Conclusion: Hp infection is closely related to inflam- matory indexes and blood lipid indexes of the patients with chronic gastritis. The above indexes can be considered as a monitoring index of chronic gastritis patients with Hp infection, so as to better assist clinical diagnosis and treatment.