七氟烷吸入麻醉对单肺通气患者血清IL-6、IL-10、MIP-2、SP-D及HMGB1水平的影响

目的:探讨七氟烷吸入麻醉对单肺通气患者血白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、巨噬细胞炎性蛋白-2(MIP-2)、人肺表面活性特异蛋白(SP-D)及高迁移率族蛋白1(HMGB1)水平的影响。方法:选择2014年9月~2016年9月于我院行单肺通气的患者108例,参照抽签法分为两组,每组各54例。对照组行常规麻醉,实验组采用七氟烷麻醉,比较两组通气前后血清IL-6、IL-10、MIP-2、SP-D、HMGB1、丙二醇(MDA)、超氧化物歧化醇(SOD)、平均动脉压(MAP)、心率(HR)水平的变化及并发症的发生情况。结果:通气前,两组血清IL-6、IL-10、MIP-2、SP-D、HMGB1、MDA、SOD、MAP、HR水平比较差异均无统计学意义(P0.05)。通气后,两组血清IL-6、IL-10、MIP-2、SP-D、HMGB1、MDA水平均较治疗前显著上升,而实验组以上指标均明显低于对照组;两组血清SOD、MAP、HR均较治疗前显著降低,且研究组低于对照组,差异均有统计学意义(P0.05)。结论:七氟烷吸入麻醉能够抑制单肺通气患者血清IL-6、IL-10、MIP-2、SP-D及HMGB1水平上升,改善机体的氧化应激状态,利于血流动力学的稳定,发挥肺部保护作用。

Influence of Sevoflurane Inhalation Anesthesia on Serum IL-6, IL-10, MIP-2, SP-D and HMGB1 Levels of Patients with Single Lung Ventilation

ABSTRACT Objective: To discuss the influence of sevoflurane inhalation anesthesia on the serum interleukin-6 (IL-6) and inter- leukin-10 (IL-10), macrophage inflammatory protein-2 (MIP-2), lung surface activity of specific protein (SP-D) and high mobility group protein 1 (HMGB1) levels of patients with single lung ventilation. Methods: 108 cases of patients with single lung ventilation who admit- ted from September 2014 to September 2016 were selected and randomly divided into two groups with 54 cases in each group. The con- trol group was given routine anesthesia, while the experimental group was given sevoflurane anesthesia, the changes of serum IL-6, IL-10, MIP-2, SP-D and HMGB1, propylene glycol (MDA), superoxide disproportionation alcohol (SOD), mean arterial pressure (MAP), heart rate (HR) levels before and after the ventilation and incidence of complications were compared between two groups. Results: Be- fore the ventilation, no significant difference was found in the serum IL-6, IL-10, the MIP-2, SP-D, HMGB1, MDA, SOD, MAP and HR levels between two groups(P>0.05). After the ventilation, the serum IL-6, IL-10, the MIP-2, SP-D, HMGB1 and MDA levels of two groups were significantly increased, which were obviously lower in the experimental group than those of the control group, the serum SOD, MAP and HR of two groups were reduced, which were lower in the experimental group than those of the control group(P<0.05). Conclusion: Sevoflurane inhalation anesthesia could decrease the serum IL-6, IL-10, MIP-2, SP-D and HMGB1 levels of patients with single lung ventilation, improve the oxidative stress state and maintain the stability of hemodynamics, which can further the protect against the lung injury.