雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果研究

目的:研究雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果,为临床治疗老年性阴道炎提供参考依据。方法:选择2016年1月~2017年5月在我院进行诊治的老年性阴道炎患者94例,随机分为观察组与对照组,每组各47例。对照组给予阴道放置乳酸菌阴道胶囊治疗,每日睡前放置1粒,连续使用一周;观察组联合采用阴道放置戊酸雌二醇治疗,每日睡前放置1片(0.5 mg),连续使用一周。比较两组的临床治疗效果,检测两组患者治疗前后血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平,并且于治疗后随访观察1年,观察两组的复发率。结果:治疗后,观察组的有效率为95.74%(45/47),明显高于对照组82.98%(39/47)](P0.05)。两组治疗前后的血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平比较差异均无统计学意义(P0.05)。治疗后6个月,观察组的复发率为4.25%(2/47),明显低于对照组14.89%(7/47)](P0.05);观察组治疗后1年的复发率为8.51%(2/47),明显低于对照组23.40%(11/47)](P0.05)。结论:雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果明显优于单纯使用乳酸菌阴道胶囊治疗,且不会对机体内的激素水平造成影响,并可有效降低其复发率。

A Clinical Study on the Clinical Efficacy of Estradiol Combined with Lacidophilin Vaginal Capsules in the Treatment of Senile Vaginitis

ABSTRACT Objective: To investigate the clinical efficacy of estradiol combined with Lacidophilin Vaginal Capsules in the treat- ment of senile vaginitis and provide references for the clinical treatment of senile vaginitis. Methods: 94 cases of patients with senile vaginitis who were treated in our hospital from January 2016 toMay 2017 were selected and randomly divided into two groups with 47 cases in each group. The control group was treated with vaginal Lacidophilin Vaginal Capsules, 1 tablets per day, for one week. The ob- servation group was treated with estradiol valerate, and placed 1 tablets (0.5 mg) before sleep for one week. The clinical therapeutic ef- fect, changes of serum progesterone and estradiol, luteinizing hormone and follicle stimulating hormone levels before and after treatment were compared between two groups, All the patients were followed-up for 1 year after treatment, the recurrence rate was observed and compared between two groups. Results: After treatment, the effective rate of observation group was 95.74%(45/47), which was signifi- cantly higher than that of the control group 82.98%(39/47)](P<0.05). No significant difference was found in the serum progesterone and estradiol, luteinizing hormone and follicle stimulating hormone levels before and after treatment between two groups(P>0.05). At 6 months after treatment, the recurrence rate of observation group was 4.25% (2/47), which was significantly lower than that of the control group14.89% (7/47)](P<0.05); at 1 year after treatment, the recurrence rate of observation group was 8.51% (2/47), which was signifi- cantly lower than that of the control group23.40%(11/47)](P<0.05). Conclusion: Estradiol combined with Lacidophilin Vaginal Capsules is superior to the single use of Lacidophilin Vaginal Capsules in the treatment of senile vaginitis, which has no affect on the serum hor- mone levels and can effectively reduce the recurrence rate.