Hepatoprotective effect of Herpetospermum caudigerum Wall. on carbon tetrachloride‐induced hepatic fibrosis in rats |
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Authors: | Xin Feng Ge‐jia Zhong Da Ji Deng Ba Bin Yang Lvyi Chen Shouying Du |
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Institution: | 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China;2. Tibetan medicine Institute, China Tibetology Research Center, Beijing, China;3. National Demonstration Center for Experimental Ethnopharmacology Education, South‐Central University for Nationalities, Wuhan 430074, China;4. School of Pharmaceutical Sciences, South‐Central University for Nationalities, Wuhan 430074, China |
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Abstract: | Tibetan medicine Herpetospermum caudigerum Wall. (HCW) has long been employed to treat hepatitis, inflammatory diseases and jaundice according to the records of “The Four Medical Tantras” in China. This study was investigated to explore the protective effects of HCW on hepatic fibrosis and the possible mechanism in a rat model. Hepatic fibrosis was established by intragastric administration of 3 ml/kg carbon tetrachloride (CCl4) twice a week for 6 weeks. CCl4‐treated rats were received HCW (1 and 3 g/kg/d) and silymarin (0.1 g/kg/d) from 3 to 6 weeks. The results showed that HCW could significantly decrease the levels of AST, ALT, HA, LN, PCIII, Col IV, TNF‐α, IL‐1β and IL‐6. Moreover, HCW could effectively inhibit collagen deposition and reduce the pathological damage. Analysis experiments finally exhibited that HCW was able to markedly inhibit hepatic fibrosis by modulating the expressions of NF‐κB p65, IκBα, Samd3 and TGF‐β1 proteins. Therefore, our results suggest that HCW has hepatoprotective activity against CCl4‐induced hepatic fibrosis in rats by regulating the inflammatory responses. |
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Keywords: | carbon tetrachloride hepatic fibrosis Herpetospermum caudigerum Wall inflammation Tibetan medicine |
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