Profile of common prostate cancer risk variants in an unscreened Romanian population |
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| Authors: | Paul D Iordache Dana Mates Bjarni Gunnarsson Hannes P Eggertsson Patrick Sulem Júlíus Guðmundsson Stefania Benónísdóttir Irma Eva Csiki Stefan Rascu Daniel Radavoi Radu Ursu Catalin Staicu Violeta Calota Angelica Voinoiu Mariana Jinga Gabriel Rosoga Razvan Danau Sorin Cristian Sima Daniel Badescu Nicoleta Suciu Viorica Radoi Andrei Manolescu Thorunn Rafnar Bjarni V Halldórsson Viorel Jinga Kári Stefánsson |
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| Institution: | 1. School of Science and Engineering, Reykjavik University, Reykjavik, Iceland;2. National Institute of Public Health, Bucharest, Romania;3. deCODE genetics/AMGEN, Reykjavik, Iceland;4. Urology Department, ‘Prof. Dr. Th. Burghele’ Clinical Hospital, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania;5. Department of Medical Genetics, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;6. Carol Davila University of Medicine and Pharmacy, Dr. Carol Davila Central University Emergency Military Hospital, Bucharest, Romania;7. Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland |
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| Abstract: | To find sequence variants affecting prostate cancer (PCA) susceptibility in an unscreened Romanian population we use a genome‐wide association study (GWAS). The study population included 990 unrelated pathologically confirmed PCA cases and 1034 male controls. DNA was genotyped using Illumina SNP arrays, and 24.295.558 variants were imputed using the 1000 Genomes data set. An association test was performed between the imputed markers and PCA. A systematic literature review for variants associated with PCA risk identified 115 unique variants that were tested in the Romanian sample set. Thirty of the previously reported SNPs replicated (P‐value < 0.05), with the strongest associations observed at: 8q24.21, 11q13.3, 6q25.3, 5p15.33, 22q13.2, 17q12 and 3q13.2. The replicated variants showing the most significant association in Romania are rs1016343 at 8q24.21 (P = 2.2 × 10?4), rs7929962 at 11q13.3 (P = 2.7 × 10?4) and rs9364554 at 6q25.2 (P = 4.7 × 10?4). None of the variants tested in the Romanian GWAS reached genome‐wide significance (P‐value <5 × 10?8) but 807 markers had P‐values <1 × 10?4. Here, we report the results of the first GWAS of PCA performed in a Romanian population. Our study provides evidence that a substantial fraction of previously validated PCA variants associate with risk in this unscreened Romanian population. |
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| Keywords: | prostate cancer
GWAS
Romania genome‐wide association study unscreened population |
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