Effect of 2-deoxyglucose, α-methylglucoside,and glucosamine on aflatoxin production by Aspergillus parasiticus |
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Authors: | Robert L Buchanan Lori A Ocker Heidi G Stahl |
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Institution: | (1) Eastern Regional Research Service, Agricultural Research Service, U.S. Department of Agriculture, 600 East Mermaid Lane, 19118 Philadelphia, PA, USA |
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Abstract: | The effects of 2-deoxyglucose (2-DOG), -methylglucoside (-MG), and glucosamine (GA) on aflatoxin production by Aspergillus parasiticus were studied using conidia-initiated and replacement cultures. In conidia-initiated, 2-DOG, -MG, and GA supported varying amounts of growth when employed as sole carbon sources. In both conidia-initiated and replacement cultures, 2-DOG, but not -MG nor GA, as sole carbon sources support toxin formation. None of the compounds inhibited aflatoxin production when used in combination with glucose. It appears that neither 2-DOG, -MG, nor GA can be considered nonmetabolizable analogs of glucose in A. parasiticus.Abbreviations YES
yeast extract sucrose
- PMS
peptone-mineral salts
- 2-DOG
L-deoxyglucose
- -MG
-methylglucoside
- GA
glucosamine |
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Keywords: | Aflatoxins Aspergillus parasiticus Glucose analogs |
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