Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors |
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| Authors: | Fioravanti Rossella Bolasco Adriana Manna Fedele Rossi Francesca Orallo Francisco Yáñez Matilde Vitali Alberto Ortuso Francesco Alcaro Stefano |
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| Affiliation: | Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma La Sapienza P.le Aldo Moro, 5, 00185 Rome, Italy. rossella.fioravanti@uniroma1.it |
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| Abstract: | A series of N-substituted-3-[(2'-hydroxy-4'-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B. |
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