| 乳腺癌干细胞分选及相关信号通路研究进展 |
| |
| 引用本文： | 吴海歌,吴晨,姚子昂,高晨慧,李倩.乳腺癌干细胞分选及相关信号通路研究进展[J].生命科学,2014(10):1067-1072. |
| |
| 作者姓名： | 吴海歌 吴晨 姚子昂 高晨慧 李倩 |
| |
| 作者单位： | 大连大学生命科学与技术学院; |
| |
| 基金项目： | 国家自然科学基金项目(81373429);国家自然科学基金青年科学基金项目(30901875) |
| |
| 摘 要： | 肿瘤干细胞是指存在于肿瘤组织中的具有干细胞特性,即能够多向分化和自我更新的一类细胞群。随着肿瘤干细胞概念的提出,乳腺癌干细胞成为当今科研领域的一个研究热点。因此,了解如何分选乳腺癌干细胞及如何维持其"干性"对治疗及预防乳腺癌具有至关重要的意义。主要从乳腺癌干细胞分选、相关信号通路、上皮-间充质转换(EMT)等方面进行综述。
|
| 关 键 词： | 乳腺癌干细胞 干细胞分选 信号通路 |
Progress in the sorting and signaling pathways of breast cancer stem cells |
| |
| WU Hai-Ge,WU Chen,YAO Zi-Ang,GAO Chen-Hui,LI Qian.Progress in the sorting and signaling pathways of breast cancer stem cells[J].Chinese Bulletin of Life Sciences,2014(10):1067-1072. |
| |
| Authors: | WU Hai-Ge WU Chen YAO Zi-Ang GAO Chen-Hui LI Qian |
| |
| Institution: | (School of Life Science and Technology, Dalian University, Dalian 116622, China) |
| |
| Abstract: | Cancer stem cells are a group of cells in tumor tissue which have properties of stem cells and the ability of both mlti-directional differentiation and self-renewing. In recent years, with the concept of cancer stem cells proposed, much work has been focused on breast cancer stem cells （BCSC）. Understanding how to sorting BCSC and how to maintain the ＂stem＂ is crucial for treatment and prevention of breast cancer. In this paper, the progress in sorting of BCSC, related signaling pathways and epithelial-mesenchymal transition （EMT） is summarized. |
| |
| Keywords: | breast cancer stem cells sorting of stem cells signaling pathway |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
