| 耐辐射球菌DNA双链断裂修复机制研究新进展 |
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| 引用本文： | 赵烨,华跃进.耐辐射球菌DNA双链断裂修复机制研究新进展[J].生命科学,2014(11):1136-1142. |
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| 作者姓名： | 赵烨 华跃进 |
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| 作者单位： | 浙江大学原子核农业科学研究所; |
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| 基金项目： | 国家重大科学研究计划(2015CB910600);国家自然科学基金项目(31370102);浙江省教育厅科研项目(Y201329892);中央高校基本科研业务费专项基金(2013QNA6015)资助 |
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| 摘 要： | 耐辐射球菌对于电离辐射等DNA损伤剂具有极强的抗性,能够将同一个基因组中同时产生的高达100个以上的DNA双链断裂在数十小时内高效而精准地进行修复,是研究DNA双链断裂修复机制的重要模式生物。同源重组、非同源末端连接和单链退火途径作为3个主要的修复途径参与了耐辐射球菌基因组DNA双链断裂的修复过程。此外,一系列新发现的重要蛋白质,如Ppr I、Ddr B等对于耐辐射球菌基因组的修复过程同样至关重要。根据本实验室和国内外在这一研究领域近年来的报道,以不同的修复途径为线索,综述该菌DNA双链断裂修复机制的最新研究成果。
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| 关 键 词： | 耐辐射球菌 双链断裂 DNA损伤修复 同源重组 合成依赖的链退火 |
Research progress on DNA double-strand break repair in Deinococcus radiodurans |
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| ZHAO Ye,HUA Yue-Jin.Research progress on DNA double-strand break repair in Deinococcus radiodurans[J].Chinese Bulletin of Life Sciences,2014(11):1136-1142. |
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| Authors: | ZHAO Ye HUA Yue-Jin |
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| Institution: | (Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, China) |
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| Abstract: | Deinococcus radiodurans is a popular model organism to study DNA double-strand break （DSB） repair due to its high resistance to DNA damage agents such as radiation. D. radiodurans can efficiently repair more than 100 DSBs per genome copy within dozens of hours. It has been shown that homologous recombination, non-homologous end joining and single strand annealing are three major pathways involved in the DSB repair of D. radiodurans. Additionally, a series of novel proteins were also identified, which play important roles in DSB repair. In this article, we summarized the recent progresses on DSB repair in D. radiodurans by different DNA repair pathways. |
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| Keywords: | Deinococcus radiodurans double-strand break DNA repair homologous recombination extended synthesis-dependent strand annealing |
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