Coenzyme Q homologs in parasitic protozoa as targets for chemotherapeutic attack

The central role of coenzyme Q (ubiquinone) in cellular energy metabolism is well established. Recent work has implicated this molecule in a wide range of other cellular functions, including roles in growth control, plasma membrane oxidase and as a cellular antioxidant. In this review, Jayne Ellis presents an overview of the current knowledge of this important cellular component in species of parasitic protozoa, discusses current therapies using its analogs and proposes its potential roles in these organisms.