Distribution and properties of human liver nucleoside diphosphate kinase |
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| Authors: | S Dancea M Dronca N G Ionescu E Dimoftache L Jebeleanu O Barzu |
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| Affiliation: | 1. Department of Landscape Architecture, College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400715, China;2. Department of Landscape Architecture and Regional & Community Planning, College of Architecture, Planning and Design, Kansas State University, Manhattan, KS 66506, USA;3. Department of Plant Pathology, College of Agriculture, Kansas State University, Manhattan, KS 66506, USA;4. Department of Agronomy, College of Agriculture, Kansas State University, Manhattan, KS 66506, USA |
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| Abstract: | - 1.1. Human liver nucleoside diphosphate kinase is predominantly cytosolic (64%). A small fraction (9.2%) is located into the mitochondria, but an unexpectedly high activity (21%) was found in microsomes.
- 2.2. Like other sources of nucleoside diphosphate kinase, the human enzyme has a broad specificity towards nucleotides both as donors or acceptors.
- 3.3. Serum nucleoside diphosphate kinase activity in the presence of ATP and 8-bromoIDP emphasized mean values of 15 IU/1. No significant increase of serum nucleoside diphosphate kinase activity was noted in patients with acute viral hepatitis.
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