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Inhibitory effect of somatostatin on neutral amino acid transport in isolated brain microvessels
Authors:Patrizia Cardelli,Anna Fiori,&dagger  ,Vito D. Corleto,Maria Rosaria Savi,&dagger  ,Filippo Granata,&Dagger  ,Fabrizio Ceci,Giampiero Ferraguti,Rosa Luisa Potenza,&dagger  ,Gianfranco Delle Fave,§  ,Robert T. Jensen¶  , Roberto Strom
Affiliation:Department of Cellular Biotechnology and Haematology, University 'La Sapienza', Rome, Italy.
Abstract:In the presence of somatostatin-14 or some of its receptorial agonists, the uptake of large neutral amino acids by isolated brain microvessels was found to be inhibited up to 50%, no other transport system being affected. Although the luminal and abluminal sides of brain endothelial cells are both capable of taking up large neutral amino acids, only uptake from the abluminal side appears to be inhibited by somatostatin. The involvement of a type-2 somatostatin receptor was suggested by assays with a series of receptor-specific somatostatin agonists, and was confirmed by the release of inhibition caused by a specific type-2 receptor antagonist. A type-2-specific mRNA was indeed shown to be present in both bovine brain microvessels ex vivo and primary cultures of endothelial cells from rat brain microvessels.
Keywords:amino acid transport    blood–brain barrier    endothelium    somatostatin    somatostatin receptors
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