Somatostatin-like immunoreactivity in human sympathetic ganglia |
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Authors: | Dr Riitta Järvi Markku Pelto-Huikko Pauli Helen Antti Hervonen |
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Institution: | (1) Departments of Biomedical Sciences and Public Health, University of Tampere, Tampere, Finland;(2) Department of Biomedicall Sciences, University of Tampere, P.O. Box 607, SF-33101 Tampere, Finland |
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Abstract: | Summary The localization of somatostatin-like immunore-activity (SOM-LI) was examined in human lumbar sympathetic ganglia using the peroxidase-antiperoxidase method. Few of the principal neurons showed immunolabelling for somatostatin and sparse networks of nerve terminals were unevenly associated with ganglion cells. Using light microscopy, the most intense SOM-LI was seen in the perinuclear zone of the neurons. Electron-microscopically, the staining was localized on the membranes of the Golgi apparatuses. In the nerve terminals, SOM-LI was seen inside the small vesicles (40–60 nm diameter). All neurons with SOM-LI were also found to be tyrosine-hydroxylase immunoreactive when excamined with a double-staining technique. These results provide evidence that somatostatin and noradrenaline co-exist in human sympathetic neurons. |
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Keywords: | Somatostatin Sympathetic ganglion Co-existence Tyrosine hydroxylase Immunocytochemistry Human |
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