Inhibition of HIV replication by amino-sugar derivatives |
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| Authors: | G W Fleet A Karpas R A Dwek L E Fellows A S Tyms S Petursson S K Namgoong N G Ramsden P W Smith J C Son |
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| Affiliation: | Dyson Perrins Laboratory, Department of Organic Chemistry, University of Oxford, England. |
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| Abstract: | The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic. |
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