Glutathione system in young spontaneously hypertensive rats |
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Authors: | S K Lee Sundaram Arunkumar K N S Sirajudeen H J Singh |
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Institution: | (1) Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia;(2) Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia;(3) Faculty of Medicine, Level 20 S & T Building, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia; |
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Abstract: | Glutathione (GSH) forms a part of the antioxidant system that plays a vital role in preventing oxidative stress, and an imbalance
in the oxidant/antioxidant system has been linked to the pathogenesis of hypertension. The aim of this study was to investigate
the status of the GSH system in the kidney of spontaneously hypertensive rats (SHR). Components of the GSH system, including
glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and total GSH content, were measured
in the kidneys of 4, 6, 8, 12, and 16 weeks old SHR and Wistar–Kyoto (WKY) rats. Systolic blood pressure of SHR was significantly
higher from the age of 6 weeks onwards compared with age-matched WKY rats. GPx activity in the SHR was significantly lower
from the age of 8 weeks onwards when compared to that in age-matched WKY rats. No significant differences were evident in
the GPx-1 protein abundance, and its relative mRNA levels, GR, GST activity, and total GSH content between SHR and age-matched
WKY rats. The lower GPx activity suggests of an impairment of the GSH system in the SHR, which might be due to an abnormality
in its protein rather than non-availability of a cofactor. Its role in the development of hypertension in SHR however remains
unclear. |
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Keywords: | |
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