Odefy - From discrete to continuous models |
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Authors: | Jan Krumsiek Sebastian Pölsterl Dominik M Wittmann Fabian J Theis |
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Institution: | 1.Institute for Bioinformatics and Systems Biology,Helmholtz Zentrum München,Munich-Neuherberg,Germany;2.Department of Mathematics,Technische Universit?t München,Garching,Germany |
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Abstract: | Background Phenomenological information about regulatory interactions is frequently available and can be readily converted to Boolean
models. Fully quantitative models, on the other hand, provide detailed insights into the precise dynamics of the underlying
system. In order to connect discrete and continuous modeling approaches, methods for the conversion of Boolean systems into
systems of ordinary differential equations have been developed recently. As biological interaction networks have steadily
grown in size and complexity, a fully automated framework for the conversion process is desirable. |
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