A solute-binding protein for iron transport in <Emphasis Type="Italic">Streptococcus iniae</Emphasis> |
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Authors: | Lili Zou Jun Wang Baofeng Huang Mingquan Xie Anxing Li |
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Institution: | 1.Key Laboratory for Aquatic Products Safety of Ministry of Education/State Key Laboratory of Bio-control, School of Life Sciences,Sun Yat-sen University,Haizhu District,PR China |
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Abstract: | Background
Streptococcus iniae (S. iniae) is a major pathogen that causes considerable morbidity and mortality in cultured fish worldwide. The pathogen's ability
to adapt to the host affects the extent of infection, hence understanding the mechanisms by which S. iniae overcomes physiological stresses during infection will help to identify potential virulence determinants of streptococcal
infection. Grow S. iniae under iron-restricted conditions is one approach for identifying host-specific protein expression. Iron plays an important
role in many biological processes but it has low solubility under physiological condition. Many microorganisms have been shown
to be able to circumvent this nutritional limitation by forming direct contacts with iron-containing proteins through ATP-binding
cassette (ABC) transporters. The ABC transporter superfamilies constitute many different systems that are widespread among
living organisms with different functions, such as ligands translocation, mRNA translation, and DNA repair. |
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Keywords: | |
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