Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines |
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| Authors: | Saxena Anil K Rao Jyoti Chakrabarty Ruchika Saxena Mridula Srimal R C |
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| Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. anilsak@gmail.com |
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| Abstract: | A series of 1-3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines has been synthesized and evaluated for hypotensive activity. The QSAR studies indicate that resonance and hydrophobic parameters of the aryl substituents are important for hypotensive activity. The similar role of resonance parameter in describing the variance of 5-HT(2A) receptor binding affinities of these compounds suggests a possible role of 5-HT(2A) receptors in mediating the hypotensive action of title compounds. |
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