| 肝激酶B1和造血干细胞内稳态 |
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| 引用本文： | 郭晓强,刘秀敏,张昱. 肝激酶B1和造血干细胞内稳态[J]. 生命的化学, 2011, 0(5) |
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| 作者姓名： | 郭晓强 刘秀敏 张昱 |
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| 作者单位： | 解放军白求恩军医学院生化教研室;河北交通职业技术学院食品工程系; |
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| 摘 要： | 肝激酶B1(liver kinase B1,LKB1),又名丝氨酸/苏氨酸蛋白激酶11(STK11),是一种蛋白激酶,可磷酸化AMP激活的蛋白激酶和12种其他AMPK相关激酶。LKB1还是一种肿瘤抑制蛋白,生殖细胞LKB1基因突变可引发家族性黑斑息肉综合征,而体细胞突变可造成多种肿瘤发生。小鼠Lkb1的失活可导致造血干细胞(HSC)静息的丧失、快速的HSC消耗、严重的全血细胞减少和最终的致死。Lkb1缺陷的HSC细胞显示出线粒体缺陷、膜电位减少和细胞ATP耗竭。这些结果说明LKB1是一种HSC内稳态和造血过程中的新调节因子。
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| 关 键 词： | 肝激酶B1 蛋白激酶 造血干细胞 内稳态 |
Relationship between LKB1 and the homeostasis of hematopoietic stem cell |
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| GuO Xiaoqiang,Liu Xiumin,ZHANG Yu. Relationship between LKB1 and the homeostasis of hematopoietic stem cell[J]. Chemistry of Life, 2011, 0(5) |
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| Authors: | GuO Xiaoqiang Liu Xiumin ZHANG Yu |
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| Affiliation: | GuO Xiaoqiang1,Liu Xiumin2,ZHANG Yu1 1 Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081,China 2Department of Food Engineering,Hebei Jiaotong Vocational and Technical College,Shijiazhuang 050000,China |
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| Abstract: | LKB1(liver kinase B1),also called STK11(serine/threonine kinase 11),is a protein kinase which can phosphorylate AMP-activated protein kinase(AMPK) and 12 other AMPK-related kinases.LKB1 is a tumor suppressor,which mutations in germline are associated with the Peutz-Jeghers syndrome and mutations in somatic cell are observed in many kinds of cancers.inactivation of Lkb1 can cause loss of haematopoietic stem cell(HSC) quiescence,rapid HSC depletion,severe pancytopenia and subsequent lethality in mice.Lkb1-def... |
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| Keywords: | liver kinase B1 protein kinase hematopoietic stem cell homeostasis |
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