|
|||||
|
|
| Ets-1在非小细胞肺癌中的表达及其临床意义 | |
| 引用本文： | 周梅,雷淑慧,胡兴胜.Ets-1在非小细胞肺癌中的表达及其临床意义[J].生命科学研究,2011,15(4):334-338. |
| 作者姓名： | 周梅 雷淑慧 胡兴胜 |
| 作者单位： | 1. 重庆市渝北区人民医院呼吸内科,中国重庆,401120 2. 重庆市铜梁县人民医院重症医学科,中国重庆铜梁,402560 3. 四川省南充市中心医院呼吸内科,中国四川南充,637100 |
| 摘 要： | 原癌基因Ets-1,与肿瘤的发生、浸润转移、血管生成及预后密切相关.通过采用免疫组化SP法和RT-PCR技术检测非小细胞肺癌(non-small cell lung cancer,NSCLC)组织及癌旁正常组织中Ets-1的表达,并分析与临床病理特征及预后的关系.免疫组化结果显示Ets-1蛋白在NSCLC组织中的阳性率为67%(65/97),显著高于对应的癌旁正常组织0%(0/30)(P<0.001).Ets-1阳性率随着肿瘤T分期的增加、淋巴结转移和临床分期的增加而增加(P<0.05),而与性别、年龄、吸烟、组织学类型及分化程度等无关(P>0.05).RT-PCR结果显示Ets-1 mR-NA在20例癌组中和癌旁组中的相对表达强度分别为0.5570±0.0593和0.2965±0.0869(P<0.001).Kaplan-Meier生存曲线显示,Ets-1阳性组的生存时间显著低于阴性组(P<0.05).Cox多因素分析模型显示Ets-1不是NSCLC患者的独立影像因素(P>0.05).结果表明,Ets-1的表达在NSCLC的浸润和转移中扮演了重要的角色,并对NSCLC患者生存期有一定的影响. |
| 关 键 词： | 非小细胞肺癌(NSCLC) Ets-1 侵润和转移 预后 |
Expression of Ets-1 and Its Clinic Significance in Non-small Cell Lung Cancer |
|
| ZHOU Mei,LEI Shu-hui,HU Xing-sheng.Expression of Ets-1 and Its Clinic Significance in Non-small Cell Lung Cancer[J].Life Science Research,2011,15(4):334-338. | |
| Authors: | ZHOU Mei LEI Shu-hui HU Xing-sheng |
| Institution: | ZHOU Mei1,LEI Shu-hui2*,HU Xing-sheng3(1.Department of Respiratory Medicine,Yubei District People Hospital of Chongqing,Chongqing,401120,China,2.Intensive Care Unit,Chongqing Tongliang County People Hospital,Tongliang 402560,3.Department of Respiratory Medicine,Nanchong Center Hospital of Sichuan,Nanchong 637100,Sichuan,China) |
| Abstract: | Proto oncogene Ets-1,was correlated with tumorigenesis,invasion,metastasis,angiogenesis and prognosis of tumor.The expression of Ets-1 was detected by SP immunohistochemistry and RT-PCR in NSCLC and neighbouring normal lung cancer tissue,and the relationship between expression and clinico-pathologic characteristics and prognosis of NSCLC were analyzed.The positive rate of Ets-1 protein in NSCLC tissue was 67%(65/97),which is significantly higher than that in neighbouring normal lung cancer tissue 0%(0/30)(P... |
| Keywords: | non-small cell lung cancer(NSCLC) Ets-1 invasion and metastasis prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |