| 层层自组装纳米粒作为非病毒基因载体 |
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| 引用本文： | 刘春喜,张娜.层层自组装纳米粒作为非病毒基因载体[J].生命的化学,2011(4). |
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| 作者姓名： | 刘春喜 张娜 |
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| 作者单位： | 山东大学药学院; |
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| 摘 要： | 基因治疗的效果严重依赖于基因载体。与传统包封技术相比,在自组装技术基础上发展起来的以DNA为聚阴离子,与荷正电的高分子材料在溶液中形成纳米粒的方法,已成为目前最重要的非病毒基因载体制备手段,具有良好的应用前景。采用层层自组装(layer-by-layer assembly,LbL)技术可提高基因装载率,其优势还在于纳米粒表面性质的可控性:在温和的条件下实现多种材料在载体表面的固定,实现载体多功能化等。本文将对近年来国内外有关层层自组装纳米粒作为非病毒基因载体的研究进展以及本课题组在此方向的研究进行简要综述。
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| 关 键 词： | 层层自组装 纳米粒 非病毒基因载体 基因治疗 |
Research progress of layer-by-layer-assembled nanoparticles as non-viral gene delivery system |
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| Abstract: | The layer-by-layer(LbL) method for the deposition of oppositely charged polyelectrolytes on solid substrates has been well-established as a convenient approach to the bottom-up assembly of multilayered polymer films.The ease of preparation,stability of multilayers formed,nanoscale controllability of film thickness,applicability to various charged species make it be an attractive technique for the production of biomimetic structures that can find applications in biomaterialogy,biology,and gene delivery.Here,... |
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| Keywords: | layer-by-layer assembly nanoparticles non-viral gene delivery system gene therapy |
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