New promising antioxidants based on 2,6-dimethylphenol |
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| Authors: | E A Kemeleva E A Vasyunina O I Sinitsina A S Khomchenko M A Gross N V Kandalintseva A E Prosenko G A Nevinskii |
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| Institution: | (1) Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’eva 8, Novosibirsk, 630090, Russia;(2) Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia;(3) Novosibirsk State Pedagogical University, Novosibirsk, 630090, Russia |
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| Abstract: | Three new sulfur-containing derivatives of 2,6-dimethylphenol were synthesized. Their antioxidative activity, mutagenicity, and genotoxicity were examined by bacterial tests and by calculating the dominant lethal mutations in murine embryonic cells. It was shown that all the compounds synthesized have a marked antioxidative effect and have no genotoxic and mutagenic properties. One of the antioxidants, 4-(3-dodecylthiopropyl)-2,6-dimethylphenol, increases the survival of cells of both the wild-type Escherichia coli strain and bacterial strains defective in the genes of repair enzymes and has a more distinct antioxidative effect than the classic antioxidants α-tocopherol and trolox, increasing the survival of cells devoid of repair enzymes. |
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| Keywords: | oxidative stress phenol antioxidants sulfur-containing antioxidants 4-thiaalkyl-2 6-dimethylphenols |
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