Tripeptide analysis of collagen synthesized by silica-exposed fibroblast cultures |
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| Authors: | W H Pailes H Resnick |
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| Institution: | 1. Biochemistry Section, Appalachian Laboratory for Occupational Safety and Health Morgantown, West Virginia 26505, U.S.A.;2. Department of Biochemistry, West Virginia University, Medical Center, Morgantown, West Virginia 26506, U.S.A. |
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| Abstract: | The effect of silica on collagen biosynthesis by confluent monolayers of WI-38 fibroblast cultures was examined by a more comprehensive method of analysis. The presence of the particulates had no direct effect on protein (collagen) synthesis, proline incorporation or prolyl hydroxylase activity; the latter is determined by the degree of hydroxylation. Silica, however, was highly toxic to the cells. |
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