Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica |
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| Authors: | Maldonado Emma Pérez-Castorena Ana L Garcés Consuelo Martínez Mahinda |
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| Affiliation: | a Instituto de Química, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., Mexico
b Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Avenida de las Ciencias s/n, Col. Juriquilla 76230, Querétaro, Qro, Mexico |
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| Abstract: | Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7. |
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| Keywords: | Physalis philadelphica Solanaceae Withanolides Cytotoxic activity |
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