Effect of water-soluble vitamins on rat diaphragm carbohydrate metabolism |
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| Affiliation: | 1. College of Fisheries and Life, Shanghai Ocean University, Shanghai 201306, China;2. Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China;3. Jiangsu Haorun Biological Industry Group Co., Ltd, Taizhou 225300, China;4. Jiangsu Haorun National Crab Seed Technology Co., Ltd, Taizhou 225300, China;1. College of Animal Science and Technology, Sichuan Agricultural University (SICAU), Wenjiang, Chengdu, Sichuan 611130, China;2. Fisheries Institute of Sichuan Academy of Agricultural Science, Chengdu, Sichuan 611731, China;3. Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China |
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| Abstract: | Oxygen and glucose uptakes and glycogen content of isolated rat diaphragm were studied in phosphate-saline medium containing 120 mg% glucose in the presence of moderate up to very high levels of various water-soluble vitamins. Of the significant findings, calcium pantothenate, methyl-methionine-sulfonium chloride, and ascorbic acid, each at a level of 0.75 mg, depressed oxygen uptake. At the latter concentration, inositol and pyridoxine hydrochloride caused a small but definite increase in the mean glycogen level, and PABA depressed both oxygen and glucose uptake by the muscle. More physiologically significant results were obtained with α-lipoic acid, which markedly decreased the glycogen content even at a level of 5 μg, and citrovorum factor (leucovorin; 10 μg), which strongly depressed both the glucose uptake and glycogen. The effect with citrovorum factor did not extend to folic or tetrahydrofolic acids, the three being compared at a level of 1.1 μM. |
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