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Putative virulence characteristics of Stenotrophomonas maltophilia: a study on clinical isolates
Authors:Sanjay Chhibber  Ankita Gupta  Riti Sharan  Vikas Gautam  Pallab Ray
Affiliation:(1) Department of Microbiology, Panjab University, Chandigarh, India;(2) Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Abstract:
Stenotrophomonas maltophilia is an important evolving pathogen, especially in patients with cystic fibrosis (CF), but its mechanism of pathogenesis is poorly understood. The purpose of this study was to investigate the presence of potential virulence determinants in five septicemic clinical isolates of S. maltophilia. When screened for EPS biosynthesis, all five strains produced colonies on two different growth media both at 30 and 37 °C. LPS could be extracted from all strains successfully and all were positive for both cell-free and cell-bound hemolysin production but failed to agglutinate 3% human RBCs. Variation in the ability to produce protease and phospholipase C was observed. In addition, all strains were unable to produce pyochelin but were able to produce ornibactin in the form of hydroxamate derivatives. It was also observed that all strains showed adherence to mouse tracheal epithelium.
Keywords:EPS  LPS  Hemolysin  Hemagglutination  Protease  Phospholipase C  Siderophore production
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