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Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid |
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| Authors: | Kiyoshige Ochi Isao Matsunaga Minoru Shindo Chikara Kaneko |
| Institution: | Research Laboratories, Chugai Pharmaceutical Co., Ltd. Takada 3-41-8, Toshima-ku, Tokyo 171, Japan Faculty of Pharmaceutical Sciences, Kanazawa University Takara-machi, Kanazawa 920, Japan |
| Abstract: | A new synthesis of desmosterol was described using hyodeoxycholic acid (3 ,6-dihydroxy-5β-cholanic acid) as a starting material. Epidesmosterol (3-hydroxycholesta-5,24-diene) was also synthesized for the first time from the same starting material. |
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