| 非标记表面增强拉曼光谱在DNA检测中的应用 |
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| 引用本文： | 吴琼,林慧晶,徐两蒲,孙艳,林多,陈冠楠. 非标记表面增强拉曼光谱在DNA检测中的应用[J]. 激光生物学报, 2020, 29(1): 34-39. DOI: 10.3969/j.issn.1007-7146.2020.01.005 |
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| 作者姓名： | 吴琼 林慧晶 徐两蒲 孙艳 林多 陈冠楠 |
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| 作者单位： | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室,福建师范大学光电与信息工程学院,福州350007;福建省妇幼保健院,福州350001 |
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| 基金项目： | 国家自然科学基金;中央引导地方科技发展专项项目;福建省高等学校杰出青年科研人才培育计划;福建省自然科学基金 |
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| 摘 要： | 表面增强拉曼光谱(SERS)是一种超灵敏的生化分析技术,已经被广泛运用于细胞、核酸、蛋白质等生物分子的检测,在生物医学领域表现出了巨大的应用潜力。近年来,将表面增强拉曼光谱技术应用于遗传物质DNA的精准检测,引起了人们广泛的关注。本文简要叙述了表面增强拉曼光谱技术的基本原理及其在DNA检测中的优势,主要介绍了非标记的DNA-SERS检测应用进展,其中包括本项目组的相关工作。研究表明,非标记DNA-SERS技术有望成为一种快速、准确的临床诊断方式。
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| 关 键 词： | 表面增强拉曼光谱 非标记 DNA检测 进展 |
Application of Label-free Surface Enhanced Raman Spectroscopy in DNA Detection |
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| WU Qiong,LIN Huijing,XU Liangpu,SUN Yan,LIN Duo,CHEN Guannan. Application of Label-free Surface Enhanced Raman Spectroscopy in DNA Detection[J]. ACTA Laser Biology Sinica, 2020, 29(1): 34-39. DOI: 10.3969/j.issn.1007-7146.2020.01.005 |
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| Authors: | WU Qiong LIN Huijing XU Liangpu SUN Yan LIN Duo CHEN Guannan |
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| Affiliation: | (Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou 350007,China;Child Health Hospital of Fujian Medical University,Fuzhou 350001,China) |
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| Abstract: | Surface enhanced Raman scattering(SERS),an ultra-sensitive biochemical analytical technology,has been widely used for the detection of biomolecules,such as cell,nucleic acid,protein,showing great potential in the field of biomedical application.In recent years,the application of SERS in accurate detection for DNA has attracted extensive attentions.This review briefly introduces the basic principle of SERS and its advantages in DNA detection.It mainly introduces label-free DNA-SERS detection,including the related work of our group.Studies have shown that label-free DNA-SERS technology is expected to become a fast and accurate clinical diagnosis approach. |
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| Keywords: | SERS label-free DNA detection advances |
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