Implantation defect in the mouse treated by WR 1339 triton: study after transplantation of ova]

Doses of 600 to 800 mg/kg of Triton W.R. 1339 from day 1 to 4 is very noxious in the mouse. In only 12 to 20% of animals the gestation is not interrupted. The morphology of the morulas examined on day 4 and the results of transplantation experiments on pseudopregnant mice gives evidence that Triton W.R. 1339 has no a direct toxic effect on the fertilized egg but acts probably on the maternal organism.