低剂量氯吡格雷治疗不稳定型心绞痛的疗效观察

目的:探讨氯吡格雷(泰嘉)治疗不稳定型心绞痛(unstable angina pectoris,UAP)的疗效。方法:102例不稳定型心绞痛患者随机分治疗组(60例)和对照组(42例),治疗组在常规药物的基础上加氯吡格雷50mg,每天1次,连用4周。对照组用常规药物治疗。两组均观察心绞痛的发作次数、24h动态心电图。结果:治疗组显效43例(79.6%),有效5例(9.3%),对照组显效23例(48.0%),有效10例(20.8%),两组相比差异有显著性(p<0.05)。治疗组心绞痛的发作次数与对照组比较明显减少(P<0.01)、24h动态心电图与对照组比较明显改善(P<0.01)。结论:UAP患者在常规药物治疗的基础上联用低剂量氯吡格雷可取得良好效果,且安全性好。

Study of effect of low-dose clopidogrel on unstable angina pectoris

Objective:To study the effect of clopidogrel on unstable angina pectoris(UAP).Methods:102 UAP patients were ran- domly divided into control group (40cases) and therapy group (60 cases).Patients in control group received a routine treatment,while patients in therapy group received ciopidogrel with a dose of 50 mg per day for 4 weeks besides the routine treatment.The frequency of angina and dynamic electrocardiogram of 24h were evaluated on the 28th day of treatment,respectively.Results:In therapy group,the treatment was significant effective in 43 cases (79.6%),and effective in other 5 cases (9.3%);In control group,the treatment was signif- icant effective in 23cases (48.0%),and effective in other 10cases (20.8%).The differences between two groups were significant (p<0. 05).Compared with control group,the frequency of angina in therapy group was obviously decreased and the manifestation of Holtor in therapy group was obviously improved.Conclusion:UAP patients can receive better effect by low-dose clopidogrel than general treat- ment.