The effect of mesenchymal stromal cells on doxorubicin-induced nephropathy in rats |
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| Authors: | Hualin Ma Yaojiong Wu Wanfan Zhang Yong Dai Furong Li Ying Xu Yunshuai Wang Huiying Tu Wuxian Li Xinzhou Zhang |
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| Affiliation: | 1. Department of Nephrology, Shenzhen People''s Hospital, Second Clinical Medical College, Jinan University, Shenzhen, China;2. Shenzhen People''s Hospital, Second Clinical Medical College, Jinan University, Shenzhen, China;3. Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China;4. Department of Rehabilitation, Chancheng District Central Hospital of Foshan City, Foshan, China;1. Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;2. Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;3. Cardiovascular Physiology, Centre for Biomedicine and Medical Technology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;4. German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany;5. Department of Neurosurgery and Centre for Stroke Research, Charite Universiätsmedizin Berlin, Berlin, Germany;6. Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg Germany;1. Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China;2. Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA;3. Medical Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA;4. Department of Pathology, University of Miami School of Medicine, Miami, FL 33136, USA;1. Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Beijing 100048, PR China;2. Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China;3. Department of Oncology, Dongtai People’s Hospital, Dongtai 224200, PR China;4. Graduate School of Tianjin Medical University, Tianjin 300052, PR China;5. Department of Thoracic and Cardiovascular Surgery, Peking University People’s Hospital, Peking University, Beijing 100044, PR China;6. Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing 100853, PR China;7. Hainan Branch of the Chinese PLA General Hospital, Sanya, Hainan Province 572014, PR China;1. Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Copenhagen, Denmark;2. Department of Hematology and Department of Oncology, University Hospital Herlev, Copenhagen, Denmark |
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| Abstract: | Background aimsThe potential protective effects of mesenchymal stromal cells (MSCs) on some kidney diseases has been reported. However, the effect of MSCs on doxorubicin-induced nephropathy is still poorly understood.MethodsRats with doxorubicin-induced kidney injuries were treated with human cord-derived MSCs. Human MSCs were first labeled with 5-bromo-2′-deoxyuridine to track their homing in kidneys after infusion.ResultsAlleviation of proteinuria, decreased serum albumin, alleviation of lipid disorders and histologic alterations were found in rats 4 weeks after treatment with MSCs, particularly in rats that were given repeat doses. Decreases in serum levels of interleukin-6, tumor necrosis factor-α and prostaglandin E2 and decreases in messenger RNA levels of kidney tissue cylooxygenase-2 and EP4 were found in MSC-treated rats. MSC-treated rats also displayed an increase in serum interleukin-10 levels.ConclusionsThese results indicate that MSCs ameliorate doxorubicin-induced kidney injuries and inflammation, suggesting a potential clinical treatment for inflammatory kidney diseases. |
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