Probe,VK5B,is located in the same interval as the autosomal dominant adult polycystic kidney disease locus,PKD1 |
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| Authors: | V J Hyland G K Suthers K Friend R N MacKinnon D F Callen M H Breuning T Keith V A Brown P Phipps G R Sutherland |
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| Institution: | (1) Cytogenetics Unit, Adelaide Children's Hospital, 5006 North Adelaide, South Australia, Australia;(2) Institute of Human Genetics, Sylvius Laboratories, University of Leiden, NL-2333 AL Leiden, The Netherlands;(3) Collaborative Research Inc., Two Oak Park, 02139 Bedford, MA, USA;(4) Present address: Molecular Genetics Unit, Kolling Institute of Medical Research, Royal North Shore Hospital, St.Leonards, 2065 Sydney, NSW, Australia |
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| Abstract: | Summary The polymorphic DNA probe VK5B (D16S94) was mapped by genetic linkage in families from the Centre d'Etude de Polymorphisme Humain (CEPH) as being in the same interval as the autosomal dominant adult polycystic kidney disease locus (PKD1). The maximum likelihood estimate of the genetic location of VK5B using multipoint linkage analysis was 9.6cM proximal to {ie286-01} (D16S85) and 5.4cM distal to CRI-0327 (D16S63), in males. The VK5B probe may be useful in PKD1 families for prenatal and presymptomatic diagnosis of the disease. Additional typing of PKD1 families is required to determine whether the location of VK5B is distal or proximal to (PKD1). |
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