Utility of ionic liquid for Geotrichum candidum-catalyzed synthesis of optically active alcohols |
| |
Authors: | Takamasa Tanaka Noritaka Iwai Tomoko Matsuda Tomoya Kitazume |
| |
Institution: | aGraduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan |
| |
Abstract: | Ionic liquids have recognized as a solvent for Geotrichum candidum-catalyzed optical resolution and/or deracemization of racemic secondary alcohols, giving optically active alcohols. The immobilized Geotrichum candidum proceeded the enantioselective oxidation of alcohols, producing chiral alcohols in an ionic liquid. Further, deracemization of racemic alcohols was proceeded to give the corresponding chiral alcohols in high yield with excellent stereoselectivity by the Geotrichum candidum–NaBH4 system in the mixture of MES buffer solution and ionic liquid. |
| |
Keywords: | Ionic liquid Enantiomer Deracemization Enantioselective oxidation |
本文献已被 ScienceDirect 等数据库收录! |