Etanercept Attenuates Myocardial Ischemia/Reperfusion Injury by Decreasing Inflammation and Oxidative Stress |
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| Authors: | Mei Yang Jianchang Chen Jing Zhao Mei Meng |
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| Affiliation: | 1. Department of Critical Care Medicine, the Third Hospital of Jinan, Jinan, People’s Republic of China.; 2. Department of Emergency, Shandong Provincial Hospital, Jinan, People’s Republic of China.; 3. Department of Cardiology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China.; 4. Department of Critical Care Medicine, Shandong Provincial Hospital, Jinan, People’s Republic of China.; Emory University, United States of America, |
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| Abstract: | The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-α production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress. |
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