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| CDK11 P58调节细胞增殖与凋亡机制 | |
| 引用本文： | 余诗灏,孟 雁. CDK11 P58调节细胞增殖与凋亡机制[J]. 中国生物化学与分子生物学报, 2009, 25(8): 708-711 |
| 作者姓名： | 余诗灏 孟 雁 |
| 作者单位： | （中国医学科学院基础医学研究所，北京协和医学院基础学院生理学系，北京100005） |
| 摘 要： | CDK11 P58属于CDK11/PITSLRE蛋白激酶家族成员，由Cdc2L1和Cdc2L2基因编码，通过使用内部核糖体进入位点（IRES）翻译而来.它在有丝分裂、凋亡、纺锤体形成、微管稳定肿瘤发生发展和中枢神经损伤等方面均有重要作用.目前发现，CDK11 P58能与HBO1、细胞周期蛋白D3、β-1,4-半乳糖转移酶、雌激素受体、雄激素受体等相互作用.进一步研究CDK11 P58的功能将为如肿瘤和代谢疾病的医治带来新的思路. |
| 关 键 词： | CDK11P58 Cdc2L 有丝分裂 相互作用蛋白 |
| 收稿时间： | 2009-03-25 |
Mechanism of CDK11 P58 Regulated Cell Growth and Apoptosis |
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| YU Shi-Hao,MENG Yan. Mechanism of CDK11 P58 Regulated Cell Growth and Apoptosis[J]. Chinese Journal of Biochemistry and Molecular Biology, 2009, 25(8): 708-711 | |
| Authors: | YU Shi-Hao MENG Yan |
| Affiliation: | （Department of Physiology, Institute of Basic Medical Sciences, China Academy of Medical Sciences and Peking Union Medical School, Beijing 100005, China) |
| Abstract: | CDK11 P58 is a CDK11/PITSLRE protein kinase family member,encoded by Cdc2L1 or Cdc2L2 and translated by an IRES. It plays an important role in mitosis,apoptosis, spindle formation, microbule stabilization, tumorigenesis and the injury of central nervous system. CDK11 P58 was discovered to interact with HBO1, cyclin D3, β-1,4-galactosyltransferase, androgen receptor and estrogen receptor.Future studies may provide evidance for its potential for the treatment of tumor and metabolic diseases. |
| Keywords: | CDK11P58；Cdc2L；mitosis；interact protein |
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