Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension |
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Authors: | Sławomir Tubek |
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Institution: | (1) Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole;(2) Clinic of Cardiology, Medical Academy, Wrocław, Prószkowska Str. 70, 45-758 Opole, Poland |
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Abstract: | Increased gastrointestinal absorption and urinary excretion of zinc has been confirmed in experimental and clinical studies
on primary arterial hypertension as a result from changes of intracellular and extracellular zinc content. In arterial hypertension,
the levels of zinc in serum, lymphocyte, and bone decrease while increasing in heart, erythrocytes, kidney, liver, suprarenal
glands and spleen. These changes result in the loss of zinc homeostasis that leads to various degrees of deficiency, not entirely
compensated by nutritional factors or increased absorption in the gastrointestinal tract. Loss of zinc homeostasis can be
both cause and effect of high blood pressure. In the present review, the role of zinc metabolism changes and its mechanisms
in arterial hypertension are discussed. |
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Keywords: | Zinc blood pressure arterial hypertension |
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