CetSINEs and AREs are not SINEs but are parts of cetartiodactyl L1 |
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Authors: | Masato Nikaido Norihiro Okada |
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Institution: | (1) Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, JP |
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Abstract: | Short interspersed repetitive elements (SINEs) are widely distributed among the genomes of eukaryotes. We proposed previously
that a SINE should be defined by the presence of a region homologous to a tRNA or to 7SL RNA, together with A-box and B-box
promoter sequences, in order to distinguish SINEs from other short repetitive sequences, such as short segments of LINEs (long
interspersed repetitive elements; Okada et al. Gene 205, 229–243, 1997). Numerous SINE sequences have been deposited to date
in DNA databases. In some cases, however, designation of a particular sequence is problematic when the short repetitive sequence
has been defined as a SINE without reference to the presence or absence of promoter elements specific for RNA polymerase III.
We demonstrate here that four different sequences, namely, ARE1p, ARE2p, CetSINE1, and CetSINE2, each of which has been reported
as a SINE, are, in fact, only partial sequences of members of a new subfamily of L1. We also demonstrate that members of this
subfamily are distributed specifically among the genomes of cetartiodactyls.
Received: 3 May 2000 / Accepted: 22 August 2000 |
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