血浆N端脑钠肽前体与COPD合并慢性肺源性心脏病患者肺动脉压的相关性分析

目的探讨血浆N端脑钠肽前体与COPD合并慢性肺源性心脏病患者肺动脉压的相关性。方法将我院收治的94例COPD稳定期患者,根据心脏彩超检查明确合并慢性肺心病患者分为观察组46例,单纯COPD患者分为对照组48例,采用化学发光法测定两组患者血浆NT-proBNP水平,心脏彩超检查两组患者右心室前壁厚度、右心室舒张末期内径、左室射血分数、主肺动脉宽度、肺动脉压,并进行比较。结果与对照组比较,观察组血浆NT-proBNP水平明显升高(P0.05),右心室前壁厚度、右心室舒张末期内径、主肺动脉宽度、肺动脉压明显升高(P0.05)。血浆NT-proBNP水平与肺动脉压成明显正相关(r=-0.284,P0.01)。结论 COPD合并慢性肺心病患者血浆NT-proBNP水平升高,有助于评估肺动脉高压的严重程度。

Association of serum N-terminal pro-BNP level with pulmonary artery pressure in patients with COPD complicated chronic pulmonary heart disease

Objective This study was designed to investigate the association of serum N‐terminal pro‐BNP level with pulmonary artery pressure in patients with chronic obstructive pulmonary disease (COPD) complicated chronic pulmonary heart disease(CPHD) . Methods A total of 94 patients with COPD were enrolled in the present stud‐y .All the patients were classified as COPD with CPHD(observation group ,n=46) or COPD without CPHD(con‐trol group ,n=48) based on the presence of CPHD or not .Serum NT‐proBNP levels were compared between two groups by electrochemistry ,and right ventricular anterior wall thickness (RVAWT ) ,right ventricular end‐diastolic (RVED) ,left ventricular ejection fraction (LVED) ,pulmonary artery diameter (PAD) ,systolic pulmonary artery pressure(SPAP) were compared between two groups by Echocardiography . Results Serum NT‐proBNP levels was significantly higher in observation group than that in control group (P< 0 .05) .RVAWT ,RVED ,PAD and SPAP were significantly higher in observation group than that in control group (P<0 .05) .Serum NT‐proBNP lev‐els was significantly and positively correlated with SPAP (P<0 .01) . Conclusion Serum NT‐proBNP levels in patients with COPD complicated CPHD was increased significantly ,which helped to assess the severity of pulmona‐ry hypertension .