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Methenamine-Silver Staining: a Simple and Sensitive Staining Method for Senile Plaques and Neurofibrillary Tangles |
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| Authors: | Chie Haga Kenji Ikeda Kiyoshi Iwabuchi Haruhiko Akiyama Hiromi Kondoh Kenji Kosaka |
| Institution: | a Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan b Department of Psychiatry, Yokohama City University School of Medicine, Yokohama 236, Japan |
| Abstract: | An improved methenamine-silver impregnation method is presented which exhibits sensitivity for amyloid substances comparable to that of anti-β protein immunostaining. In optimally treated sections, this technique stained both β-amyloid deposits and neurofibrillary tangles, which are known to have a β-pleated structure. This simple procedure allows a large number of sections to be stained for routine examination. |
| Keywords: | methenamine-silver anti-β protein immunostaining amyloid deposits senile plaques diffuse plaques Alzheimer-type dementia neurofibrillary tangles |
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