Synthesis and Biological Activity of the Lipophilic Derivatives of N- Acetyl-1-thiomuramoyl-l-alanyl-d-isoglutamine |
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| Authors: | Akira Hasegawa Shuichi Hara Makoto Kiso Ichiro Azuma |
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| Institution: | 1. Department of Agricultural Chemistry, Gifu University, Gifu 501–11, Japan;2. Institute of Immunological Science, Hokkaido University, Sapporo 060, Japan |
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| Abstract: | A variety of the lipophilic derivatives at C-1 and C-6 in N-2-O-(2-acetamido-2,3-dideoxy-1-thio-β-d-glucopyranose-B-yl)-d-lactoy]-l-alanyl-(N1-fatty acyl)-d-isoglutamine methyl esters were synthesized from 2N-acetyl-1-S-acetyl-4,6-O-isopropylidene-1-thiomuramoyl-l-alanyl-d-isogluta-mine methyl ester. Their immunoadjuvant activity in guinea-pigs, and the protective effect in mice infected with Escherichia coli (E-77156) were examined. |
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| Keywords: | binary vector gateway cloning reporter tag |
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