Mutagen Formation in the Reaction of Nitrite with the Food Components Analogous to Sorbic Acid |
| |
Authors: | Toshihiko Osawa Mitsuo Namiki |
| |
Institution: | Department of Food Science and Technology, Nagoya University, Chikusa, Nagoya 464, Japan |
| |
Abstract: | Mutagen formation by the reaction of sodium nitrite with some sorbic acid analogs was investigated by using the microbial mutagenicity tests (rec-assay and Ames test) together with chemical examination using TLC, and it became clear that the conjugated dienoic carbonyl structure is essential for mutagen formation by the reaction with nitrite By a large scale reaction of sodium nitrite with sorbic acid methyl ester, 5-nitro-2,4-hexadienoic acid methyl ester and ethylnitrohc acid were isolated and identified as the mam mutagens The results led to the assumption that a nitro group adjacent to the double bond is an important factor to develop mutagenicity |
| |
Keywords: | cytochrome P450 oleanolic acid queretaroic acid hydroxylation |
|
|