Antimutagenic Effects of Autoxidized Linoleic and Oleic Acids on UV-Induced Mutagenesis in Escherichia coli |
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| Authors: | Katsuhiro Aikawa Yoshiro Komatsu |
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| Institution: | National Institute of Animal Industry, Tsukuba Norindanchi P.O. 5, Ibaraki 305, Japan |
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| Abstract: | The antimutagenic effects of autoxidized linoleic and oleic acids on mutagenesis by UV irradiation were investigated in Escherichia coli B/r WP2 and WP2s uvrA. When added to an agar medium, these autoxidized acids greatly reduced the number of Trp+ revertants without significant effects on survival in WP2, but no such effect was observed with WP2s uvrA. The presence of autoxidized linoleic acid decreased the survival of WP2s uvrA greatly and CM571 recA somewhat. It thus appears that the autoxidized unsaturated fatty acid has antimutagenic effects on the wild type strain and lethal effects on the genetic repair-deficient strains. |
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