Comparison of the Effects of Orally Administered Linoleic Acid,and Its Hydroperoxides and Secondary Autoxidation Products on Hepatic Lipid Metabolism in Rats |
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| Authors: | Hitoshi Ashida Kazuki Kanazawa Masato Natake |
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| Institution: | 1. Department of Utilization of Biological Resources, Nada-ku, Kobe, Hyogo 657, Japan;2. Department of Agricultural Chemistry, Kobe University, Nada-ku, Kobe, Hyogo 657, Japan |
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| Abstract: | Linoleic acid, and its hydroperoxides and secondary autoxidation products were orally administered to rats (400 mg/rat). Their effects on hepatic lipid metabolism were examined. Linoleic acid reduced the activities of de novo synthesis of fatty acids and acetyl-CoA carboxylase. It decreased the CoASH level and caused the accumulation of long-chain acyl-CoA. Hydroperoxides changed the compositions of unsaturated fatty acids in the hepatic lipids and lowered the content of neutral lipids. Secondary products stimulated carnitine palmitoyltransferase and decreased the content of neutral lipids. They reduced the activities of de novo synthesis of fatty acids and acetyl-CoA carboxylase, and the levels of CoASH and acetyl-CoA. Thus, the effect of secondary products was apparently different from those of linoleic acid and its hydroperoxides. |
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| Keywords: | Candida boidinii growth promoting substance reduction of lag phase yeast extract |
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