A New Natural Quinone, 2-Methyl-3-II,III,VIII,IX-octahydromultiprenyl9-1,4-naphthoquinone Isolated from Streptomyces albus |
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| Authors: | Yuzo Yamada Chin Fei Hou Joji Sasaki Yasutaka Tahara Hajime Yoshioka |
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| Affiliation: | Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Shizuoka University, Shizuoka 422, Japan |
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| Abstract: | Purification of the precipitates obtained from the juice oil of Citrus hassaku by chromatography afforded 7-geranyloxycoumarin (aurapten) and two compounds (mp 43~45°C and 122~124°C), whose structures were determined to be epoxyaurapten and marmin on the basis of spectral evidence. These compounds were isolated from Citrus hassaku for the first time. The spasmolytic activity was tested of aurapten, epoxyaurapten, marmin and their related compounds, which were synthesized from aurapten and marmin, on the small intestine removed from a male guinea pig. Epoxyaurapten exhibited the highest activity among them against the small intestine’s contraction induced by BaCl2. |
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